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Krokodil Drug Facts
Common or street names: Crocodil, Russian Magic, Poor Man's Heroin, Zombie drug
What is krokodil (desomorphine)?
- Desomorphine, known by the street name krokodil, is a powerful opioid derivative of codeine. Like heroin and other opioids, it has a sedative and analgesic effect and is highly addictive.
- Desomorphine is a Schedule I substance in the U.S., meaning it has a high abuse potential with no accepted medical use. Other chemical names include dihydrodesoxymorphine or dihydrodesoxymorphine-D. It has been controlled in the US since 1936.
- Long-term users who inject these caustic agents into their veins can develop extreme skin ulcerations, infections, and gangrene — a discolored (green, grey, black) scale-like skin that resembles a crocodile, hence the street name “krokodil” or “crocodil”.
- Krokodil is also called “Russian Magic”, referring to its short duration of opioid intoxication (euphoria). It is called “Poor Man’s Heroin” as it is a cheaper alternative to heroin.
Krokodil is reported to contain desomorphine, a semi-synthetic morphine analogue synthesized in the 1930s. Due to illicit, home-based manufacturing it may contain other unknown ingredients. It is typically abused via the intravenous (IV) route into a vein.
Krokodil also refers to chlorocodide, a codeine derivative in the synthetic path to desomorphine. Homemade versions of the drug start with codeine, and can be ‘cooked’ similar to illicit methamphetamine (“meth”) production. Organic solvents such as gasoline, paint thinner, or lighter fluid, iodine, hydrochloric acid, and red phosphorus (from matches) are used in homemade synthesis. These dangerous chemicals are not always fully “cooked” out of the concoction when used to make illicit krokodil.
According to the DEA, in 2004 the National Forensic Laboratory Information System (NFLIS) identified two samples of desomorphine. Since that time the DEA states no other exhibits have been identified as desomorphine (up to 2019). However, a case report from 2020 notes that usage is increasing in the US, but much less than heroin.
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How is krokodil used?
- Krokodil is typically used by the intravenous (IV) route.
- According to reports, the drug is fast-acting within 2 to 3 minutes and 10 to 15 times more potent than morphine, and three times as toxic. In fact, when the toxic chemicals are removed, quite often what is left is desomorphine, a compound very similar to heroin.
- After a rapid onset, the euphoric effects may last less than two hours. Due to the short duration of the “high”, many users find themselves in a rapid repetition of drug use to avoid withdrawal symptoms that resemble heroin.
- Due to the drug’s rapid onset but short duration of action and frequent administration, quick physical dependence may occur.
What are the side effects of krokodil?
There have been multiple unconfirmed news reports of users in the U.S. and Canada who have had extreme skin ulcerations, infections and scale-like skin due to use of krokodil. The most common complications reported thus far from krokodil injection appears to be serious vein damage, soft tissue infections, necrosis and gangrene.
According to reports, the localized soft tissue effects occur relatively quickly after the use of krokodil. There have been news reports of amputations. It appears that ulcerations may occur locally at the drug injection site or also at remote areas of the body. There may be further organ or central nervous system damage.
Reported health hazards due to krokodil injection use include:
- blood vessel damage (thrombophlebitis)
- open ulcers, gangrene
- skin and soft tissue infections
- need for skin grafts and surgery
- limb amputations
- pneumonia
- blood poisoning (bacteremia)
- meningitis
- rotting gums or tooth loss
- blood-borne virus transmission (such as HIV and HCV due to needle sharing)
- bone infections (osteomyelitis) and osteonecrosis
- speech and motor skills impairment
- memory loss and impaired concentration
- liver and kidney damage
- overdose
- powerful respiratory depressant effect (slowed or stopped breathing)
- death
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Is krokodil in the U.S?
There were few reports of krokodil use in the U.S. until September 2013 when a poison control center in Phoenix, Arizona received inquiries about the product. Additional reports have surfaced from Illinois and Oklahoma.
Is krokodil addictive?
Addiction is an obvious problem with krokodil use due to its high opioid potency and short duration of effect. Frequent administration may lead to binge patterns that can last for days. Users are at increased risk for exhaustion due to sleep deprivation, memory loss, and problems with speech. Variations in potency or “homemade” recipes can put users at increased risk of overdose.
repeated administration of desomorphine with short intervals in cancer patients with severe pain showed that desomorphine produced a high degree of addiction liability.
Another less obvious risk with krokodil use is that those who are afflicted with gangrene and other side effects may delay seeking much-needed medical treatment due to fear of legal action. In addition, the desire for continued krokodil administration to prevent withdrawal effects may prevent users from finding treatment.
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krokodil & cocaine comparison
Cocaine and krokodil belong to completely different types of illegal narcotics and have different biological mechanisms, physical effects, and sources. Krokodil is a created synthetic opioid that is extremely poisonous, whereas cocaine is a potent stimulant of the central nervous system produced from plants.
| Feature | Krokodil (Desomorphine) | Cocaine |
|---|---|---|
| Drug Class | Synthetic Opioid | Central Nervous System Stimulant |
| Primary Effect | Extreme sedation, pain relief, central nervous system depression | Intense euphoria, hyper-alertness, burst of energy |
| Origin / Composition | Home-cooked mixture of codeine, gasoline, paint thinner, and hydrochloric acid | Extracted from the leaves of the South American Erythroxylum coca plant |
| Primary Method of Use | Intravenous (IV) injection | Snorting, smoking (crack), or intravenous injection |
| Duration of High | Very short (typically less than 2 hours) | Short (5 to 30 minutes depending on method) |
| Fatal Overdose Risk | Severe respiratory failure (breathing stops) | Cardiovascular catastrophe (heart attack, stroke, seizure) |
| Life Expectancy / Toxicity | Extreme; frequent users typically survive only 2 to 3 years | Chronic long-term toxicity, but typically measured over years to decades |
What are Stimulants
Stimulants are a class of psychoactive drugs that increase activity in the brain, impacting alertness and mood. In psychology, stimulants are generally defined as substances that excite functional activity in the central nervous system.1
Some stimulant drugs are legal and consumed widely, while others are illegal to possess and use. Drugs classified as stimulants include:
- Caffeine
- Nicotine
- Cocaine
- Methamphetamine
- Prescription stimulants
Each of these stimulants has unique properties and mechanisms of action. But they also share many commonalities, one of which is that all of them can be highly addictive, causing negative effects on health and wellness.
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